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The error "central_filter defer (-17): error in filter file: unknown filtering command r_subject: near line 22 of filter file" or "error in filter file: "and" or "or" or "then" expected near line ..." found in your exim_mainlog can result when a vfilter rule does not agree with the server. You can clear these offending rules out when using cPanel by going into /etc/vfilters and clearing out the domain file.
Example:
echo > thedomainwithissue.com
central_filter defer (-17): error in filter file: unknown filtering command r_subject: near line 22 of filter file
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